منابع مشابه
Hypercalcaemia of malignancy: two primaries in the same patient.
Hypercalcaemia of malignancy (HCM) is a grave emergency in a cancer patient. Metastatic breast cancer and multiple myeloma are two of its important causes. Moreover, breast cancer is a predisposing factor for secondary malignancy, multiple myeloma being one of them. We report an interesting case of HCM in which we labelled the first two admissions to metastatic breast cancer. However, on third ...
متن کاملParathyroid hormone-related protein as a tumour marker in humoral hypercalcaemia associated with occult malignancy.
The tumour-derived factor PTH-related protein (PTHRP) is the primary humoral factor responsible for hypercalcaemia in patients with solid tumours. In a woman presenting with anaemia and hypercalcaemia, the finding of raised plasma PTHRP and undetectable serum PTH concentrations led to further investigations and the subsequent identification of a uterine tumour. No evidence of tumour spread was ...
متن کاملRelative contribution of humoral and metastatic factors to the pathogenesis of hypercalcaemia in malignancy.
Some relations between metastatic bone disease and calcium homoeostasis were determined in a consecutive series of 81 patients with solid malignant tumours attending for radionuclide bone scans. Biochemical evaluation showed that bone resorption from metastatic disease was generally not enough to account for hypercalcaemia. While skeletal metastases were present in about half of the patients wh...
متن کاملHypercalcaemia.
tivity, and cardiovascular risk factors in hypopituitary adults. J Clin Endocrinol Metab 1995;80:153–9. 12 Bulow B, Hagmar L, Mikoczy Z, Nordstrom CH, Erfurth EM. Increased cerebrovascular mortality in patients with hypopituitarism. Clin Endocrinol (Oxf) 1997;46:75–81. 13 Fowelin J, Attrall S, Lager I, Bengtsson BA. Effects of treatment with recombinant human growth hormone on insulin sensitivi...
متن کاملHypercalcaemia of malignancy and basic research on mechanisms responsible for osteolytic and osteoblastic metastasis to bone.
Calcium homeostasis is a tightly regulated process involving the co-ordinated efforts of the skeleton, kidney, parathyroid glands and intestine. Neoplasms can alter this homeostasis indirectly through the production of endocrine factors resulting in humoral hypercalcaemia of malignancy. Relatively common with breast and lung cancer, this paraneoplastic condition is most often due to tumour prod...
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ژورنال
عنوان ژورنال: BMJ
سال: 1989
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.298.6686.1468